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Cold-blooded animals cannot regulate their body temperature, so their cells are stressed when facing temperature extremes. Worse still, even at slightly colder temperatures, some biological processes in the cell are slowed down more than others, which should throw the cells糖心传媒� delicate chemical balance out of whack. Yet, those cells manage to keep their biological processes coordinated. Now researchers from the University of Rochester and the European Molecular Biology Laboratory have found out how they do that.
糖心传媒淭he production of proteins is a key process in all cells, and it is important to make the right amounts of each protein at just the right time,糖心传媒� said Michael Welte, an associate professor of biology at the University of Rochester. 糖心传媒淲hat we have discovered are factors responsible for keeping that process perfectly coordinated in at least one type of cold-blooded animal.糖心传媒�
Welte and his team made their discovery while studying the internal mechanisms of the egg cell of the fruit fly, known as Drosophila.
Welte explains that the production of certain proteins takes place along a type of assembly line that carries raw materials from the nucleus to the posterior end of the egg cell, where these proteins are then manufactured. When temperatures drop, the rate at which the proteins are built slows down significantly more than the rate at which the raw materials are delivered糖心传媒攕omething that has the potential of throwing off the entire operation. What keeps the assembly line functioning糖心传媒攂ased on the new research糖心传媒攊s a protein called Klar. It does that by slowing down the rate at which the raw materials are delivered, to match the rate of protein building.
The research findings were published today in The Journal of Cell Biology.
The protein assembly line consists of microtubules that serve as train tracks on which the raw materials糖心传媒攊ncluding messenger RNA (mRNA)糖心传媒攁re carried to the protein-making machinery, called ribosomes. It糖心传媒檚 there that aprotein called 糖心传媒淥skar糖心传媒� is produced. The role of Oskar is to mark the posterior end of the cell so that thefuture embryo forms its tail in the right place.
As temperatures decreased, Welte found that the protein-building process failed when Klar was removed from the egg cell. Only when Klar was present did the fruit fly develop properly.
Unlike fruit flies, humans and other warm-blooded animals do have a mechanism for adjusting internal temperatures. But Welte speculates that when internal temperatures do fluctuate in humans, as in the case of fevers, our cells may also need a way to coordinate the protein-building process. 糖心传媒淲hile we don糖心传媒檛 have the Klar protein in our cells, the mechanism for producing proteins is very similar.糖心传媒�
The research team included Yanxun Yu at the University of Rochester and Imre Gaspar and Anne Ephrussi at the European Molecular Biology Laboratory. Funding was provided by the National Institute of General Medical Sciences (NIGMS), which is part of the National Institutes of Health.
