Women of Invention is a News center series of profiles of women at the University who hold international patents. More than half of the University糖心传媒檚 patent applications from 2011 to 2015 include women.
From the very beginning of her career, has looked for big problems to solve. Now she糖心传媒檚 doing something about a very big problem indeed: Loss of vision after a stroke or brain injury.
糖心传媒淲hen people have a stroke that affects the motor system, they are sent to rehab as soon as possible,糖心传媒� says Huxlin, the James V. Aquavella, M.D. Professor in Ophthalmology at the 糖心传媒淭hey get retrained to use a weak arm or leg, and to regain speech.糖心传媒�
糖心传媒淏ut if they have a stroke that affects vision, which involves more than 30 percent of our brain matter and is our dominant sense, they are told there糖心传媒檚 essentially nothing that can be done.糖心传媒� They糖心传媒檙e told 糖心传媒渢hey should go home and get used to being blind.糖心传媒�
Even more frustrating for Huxlin is when applications for disability are challenged because a stroke or injury victim 糖心传媒渟till has糖心传媒� a 50 percent field of vision. With only a 50 percent field of vision, it糖心传媒檚 difficult to spot a car coming from the right or left, to detect objects, to navigate through an airport, and even糖心传媒揺specially if the 糖心传媒渂lind area糖心传媒� is to the right of center糖心传媒攖o keep your eye anchored on the line of a book you are trying to read.
糖心传媒淎ll of these things become excruciatingly difficult,糖心传媒� Huxlin says.
Huxlin has developed a 糖心传媒減hysical therapy糖心传媒� for the visual system糖心传媒攁 set of exercises that stimulates use of visual information by undamaged portions of the visual cortical system. With repeated stimulation, these undamaged portions can learn to effectively process visual information that is not filtered by the damaged primary visual cortex, partially restoring conscious visual sensations.
How? With a simple, computer-based device that requires vision-impaired stroke victims to fixate on a spot in front of them. Then, without shifting their eyes from that spot, they are asked to describe small circles of striped patterns or moving dots that are flashed in their blind zone. At first, they may see little, perhaps only just 糖心传媒渟ensing糖心传媒� the stimuli. But eventually, her studies show, the patients are able to actually 糖心传媒渟ee糖心传媒� them and describe them relatively accurately. Their visual system has re-learned to interpret a visual signal from their blind zone.
Huxlin糖心传媒檚 device includes multiple improvements over previous eye-training systems. For example, it incorporates eye tracking to ensure that patients aren糖心传媒檛 inadvertently 糖心传媒渃heating糖心传媒� by turning their eyes toward the stimuli.
The technology has been patented and licensed to Envision Solutions. The company is currently running a three-site clinical trial with the technology. Huxlin is also collaborating with in the Chester F. Carlson Center for Imaging Science at nearby Rochester Institute of Technology to develop virtual reality headsets with integrated eye tracking that patients could use at home糖心传媒攔endering in-home, long-term therapy as effective as it is when it糖心传媒檚 performed in the Huxlin lab.
At home with science
When Huxlin first came to Rochester in 1995, she intended to stay only two years.
Born in Romania, she moved with her family to Belgium at age four, and then to Sydney, Australia, at age 13.
Her parents, both geologists, 糖心传媒渨ere always talking about science at home,糖心传媒� she says. 糖心传媒淪o, I grew up in an environment where being intellectually active and curious was encouraged and rewarded.糖心传媒�
After Huxlin finished high school, the British education system in Australia enabled her to go directly into the University of Sydney School of Medicine to pursue BS and PhD degrees in neuroscience. 糖心传媒淩ight away I went looking for labs to do research in during my spare time,糖心传媒� she says.
Fortunately, she was welcomed into the lab of Ann Sefton, a vision scientist who has done pioneering work both in understanding how visual information is regulated as it passes from the eye to the cerebral cortex, and in describing how visual centers of the brain are formed during development. During six years of undergraduate and PhD studies, Huxlin gained an understanding of the visual system, then developed animal models to help study eye damage in the lab.
She culminated her studies with a prestigious, four-year C.J. Martin Early Career Fellowship, which allowed her to spend the first two years overseas. She came to the University of Rochester to study with William Merigan and Tatiana Pasternak, professors of ophthalmology, neurobiology and anatomy, and both long-standing members of the
And then she met her husband糖心传媒擪eith W. Nehrke 糖心传媒�94, currently a professor of medicine in the Nephrology Unit. She forfeited the last two years of her fellowship糖心传媒攁nd stayed at Rochester.
Collaboration leads to breakthrough
She has no regrets. 糖心传媒淚 became plugged in immediately with the Center for Visual Science, which has been vital to me and my work,糖心传媒� she says. The center, founded in 1963, consists of nearly 40 糖心传媒 research labs, including faculty from seven different departments.
糖心传媒淭hey cover every aspect of vision from optics to computational neuroscience, from genetics to higher level cognition involving vision decision making,糖心传媒� Huxlin says. 糖心传媒淚t糖心传媒檚 just so expansive. That糖心传媒檚 what糖心传媒檚 kept me here, professionally.糖心传媒�
Indeed, her subsequent work with the center and several of its members, including current director David Williams, the William G. Allyn Professor of Medical Optics, led to a collaboration that may transform the way human vision is corrected. At the time, the group was working with Bausch and Lomb and Scott McRae, the University糖心传媒檚 Lasik surgery expert, on ways to improve the procedure.
They invited Wayne Knox, a professor of optics, to describe how he was using femtosecond lasers糖心传媒揳t high repetition rates, low pulse energies糖心传媒搕o change the properties of hydrogel materials in ways that altered their refractive index and wave-guiding properties.
But Huxlin thought of something else.
糖心传媒淚糖心传媒檓 thinking, hmm, these were hydrogels 500 microns thick, transparent, wet … That糖心传媒檚 (the same as a) cornea,糖心传媒� she says. 糖心传媒淪o, I asked Wayne, could we use this in a living cornea? Do you think it might work?糖心传媒�
Knox agreed to give it a try.
Now, some 10 years later, the technology is licensed to The startup is continuing to work with University researchers to develop the technology so that it can write individually customized vision corrections into not only contact and intraocular lenses, but directly into patients糖心传媒� corneas. Critically, it can accomplish the task without any of the flap-cutting part of the current Lasik surgery that prevents many people from electing to have the procedure.
Recent early-stage clinical trials in humans 糖心传媒渨orked beautifully,糖心传媒� Huxlin says. 糖心传媒淭here were no adverse effects that we can tell. So, you couldn糖心传媒檛 ask for anything more.糖心传媒�
The procedure can be done in a minute or so. And, in theory, it can be done again, and again, as individuals age.
Equally exciting, she says, is the impact the technology will have on contact lenses. A company will no longer need to keep huge stocks of lenses with 糖心传媒減lus one, minus one, plus two, minus two with x amount of astigmatism,糖心传媒� Huxlin says. 糖心传媒淵ou just measure the full complement of aberrations in any individual eye, then write it into a blank contact lens. And there you, go. Absolutely custom.
糖心传媒淭his technology could totally revolutionize the approach and feasibility of laser refractive correction. And considering the myopia epidemic that is developing worldwide, it is not a moment too soon.糖心传媒�
Editor糖心传媒檚 note: As of 2024, the therapy discussed below remains experimental and is available only as part of a clinical trial. You can or email Evan Burr to find out more about ongoing or upcoming trials.
