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University remembers Andrew Kende, professor emeritus of chemistry

Andrew Kende, the Charles F. Houghton Professor of Chemistry, Emeritus, and former chair of the Department of Chemistry, in a 2003 photo. (糖心传媒 photo)

Lanny Liebeskind 糖心传媒�77 (PhD) remembers walking into Andrew Kende糖心传媒檚 lab for the first time as a new PhD student.

糖心传媒淚 remember asking Andy when I should start my research. His succinct answer, in effect, was 糖心传媒楴ow!糖心传媒櫶切拇綕 says Liebeskind, the vice provost for strategic research initiatives and Samuel Dobbs Professor of Chemistry at Emory University.

University flags will be lowered on April 19 in remembrance of Kende, the Charles F. Houghton Professor of Chemistry, Emeritus, and former chair of chemistry. He was a world renowned organic chemist and inventor who specialized in the synthesis of complex molecules, including ones used for anti-cancer treatments.

糖心传媒淚 got the message loud and clear. It was a bit like being dropped into a professional sports team where the coach is constantly challenging you to push yourself beyond the comfort level. In doing so, you grew in ways as a scholar and person that you never would have on your own.糖心传媒�

Yuh-geng Tsay 糖心传媒�77 (PhD) had a similar experience. 糖心传媒淲hen I toured Professor Kende糖心传媒檚 labs, I noticed there was a memo from him posted in each cubicle of his graduate students and post docs. Two key phrases stood out that got my attention. 糖心传媒榃hen you are here, you should roll up your sleeves and work. If you cannot manage at least two experiments at the same time, you don糖心传媒檛 belong to this group.糖心传媒�

糖心传媒淎t that moment, I knew he would be the professor I wanted to learn from,糖心传媒� says Tsay, a Venture Partner at Vivo Capital, former senior vice president and group president at Thermo Fisher Scientific, and recipient of the University糖心传媒檚 .

糖心传媒淚 am happiest when faced with a result that is truly counter to the best theories. That is when new insights into the nature of the physical world can be discovered,糖心传媒� Kende said in a University profile.

糖心传媒淗e was a very astute scientist; he had a really good nose for important problems,糖心传媒� says Robert Boeckman, the Marshall D. Gates Jr. Professor of Chemistry and recent chair of the department, who was recruited to join the faculty by Kende.

Kende also had a knack for identifying students, such as Liebeskind and Tsay, who had the potential to rise to the tops of their fields 糖心传媒� and for pushing them to excel.

糖心传媒淗e was a hard taskmaster,糖心传媒� Boeckman says. 糖心传媒淏ut the vast majority of the more than 50 PhD students and postdocs that Andy mentored went on to perform at the highest levels. 聽That糖心传媒檚 a testament to how he taught them about the importance of excellence in whatever they do.糖心传媒�

糖心传媒淭hings relate in a sensible way.糖心传媒�

Born in Budapest, Hungary, Kende emigrated to the United States with his family in 1939, and grew up in Evanston, Ill. He later described being fascinated with chemistry at six years old.

糖心传媒淚t糖心传媒檚 always seemed to me an interesting way to structure information,糖心传媒� he said. 糖心传媒淭hings relate in a sensible way.糖心传媒�

At an early age, Kende exemplified the excellence he would later encourage in his students.聽 At 13 he was a Westinghouse Science Talent Search winner; at 16 he enrolled at the University of Chicago, earning a two-year degree. He studied under one Nobel laureate 糖心传媒� Robert Woodward 糖心传媒揳s a PhD student at Harvard, and under another Nobel laureate 糖心传媒� Derek Barton 糖心传媒� as a postdoc at Glasgow University.

After college, he worked for 11 years at Lederle Laboratories as a senior research scientist, research associate, and research fellow. Kende played an 糖心传媒渋nstrumental糖心传媒� role helping the company become the first to synthesize the carbon framework for tetracycline antibiotics, Boeckman says.

Kende糖心传媒檚 discoveries continued after he joined the University of Rochester in 1968.

For example, he collaborated with Alan Poland, an assistant professor of pharmacology and toxicology, in synthesizing TCDD, a highly toxic, persistent environmental contaminant resulting from the manufacture of herbicides, wood preservatives, and lubricating oils. This was an important first step in setting standards to help regulate TCDD.

In 1981, Kende and James Rizzi, a graduate student in his lab, were among the first scientists to synthesize aklavinone, which could then be modified as a less expensive, less toxic anti-tumor drug than other treatments then available.

Several of Kende糖心传媒檚 compounds were patented; in 1979 he was chosen inventor of the year by the Rochester Patent Law Association. That same year he was one of 50 U.S. scientists chosen to participate in the nation糖心传媒檚 first bilateral scientific symposium with China. Other honors included a Guggenheim Fellowship, the Rochester Section Award of the American Chemical Society, and a Fellowship from the Japanese Society for the Promotion of Science.

The Department of Chemistry has also created a named professorship in his honor.

Teaching, research, mentorship, service

Kende糖心传媒檚 passion for chemistry left little time for other interests. 糖心传媒淗is routine day started around 11 a.m. and ended about 9 at night,糖心传媒� Boeckman says.

When Kende wasn糖心传媒檛 teaching, doing research, or consulting (for the American Cancer Society, the National Institutes of Health, and for companies such as Dow, Glaxo and Bausch and Lomb), he was doing 糖心传媒渟ervice糖心传媒� — for the field of organic chemistry, for his university, and for his department.

He served for 12 years as associate editor for Organic Chemistry and was a member of the editorial boards of Organic Reactions, Chemical Reviews, Organic Synthesis and Synthetic Communications. He was a member of University committees for graduate admissions, budget, tenure and privilege, and River Campus parking; he served in the University Senate; he chaired the Scientific Advisory Board of the UR Cancer Center.

As department chair from 1979 to 1983, he worked with the University糖心传媒檚 chief science librarian to introduce chemistry undergraduates to the wonders of the computer as a new way to search for articles and information 糖心传媒渂uried in the huge and growing body of scientific literature.糖心传媒� This consisted of using an 糖心传媒渙rdinary phone糖心传媒� to dial a database, attaching the receiver to a portable computer terminal, typing in a request, and then 糖心传媒渨ithin seconds糖心传媒� getting a printout.

Kende 糖心传媒渆njoyed teaching,糖心传媒� Boeckman says, 糖心传媒渂ut his real thrill was in mentoring and training his graduate students and participating in the research they did.糖心传媒�

The lessons they learned from him 糖心传媒� about chemistry but also about working hard and achieving excellence 糖心传媒� have remained with them over the years.

Tsay, for example, remembers that whenever Kende returned from a business trip, 糖心传媒渉e would stop by the lab first to see how everyone was doing. This type of work ethic has inspired us not only to work hard, but to have a sense of urgency in everything you do. His teaching style empowered us to solve any technical challenge and to be independent problem solvers.糖心传媒�

糖心传媒淎rmed with the skills that I learned from him as a graduate student, I was able to excel in every venture that I chose to tackle,糖心传媒� Tsay says. 糖心传媒淚 was also quite fortunate that Professor Kende agreed to serve as a Scientific Advisor for one of my companies to provide guidance and advice to R&D scientists.糖心传媒�

糖心传媒淎ndy was not a man of many words,糖心传媒� says Liebeskind, who still saves a memo Kende sent to his 糖心传媒済ang糖心传媒� of grad students, chastising them for a 糖心传媒渟lump in productivity.糖心传媒�

糖心传媒淗e was succinct and to the point. He was clear in his expectations and treated everyone fairly,糖心传媒� Liebeskind says. 糖心传媒淗e impressed upon us the purity of the scientific method and the sanctity of data and critical observations married to critical analysis.

糖心传媒淗e was a perfect mentor for me at that earlier stage of my life and helped me grow and mature into the person and scientist/scholar that I became.

糖心传媒淗e is missed.糖心传媒�