Understanding recovery process could have implications for many different injuries of the central nervous system
An interdisciplinary team of University neuroscientists and neurosurgeons has used a new imaging technique to show how the human brain heals itself in just a few weeks following surgical removal of a brain tumor.
In a study featured on the cover of the current issue of the journal , the team found that recovery of vision in patients with pituitary tumors is predicted by the integrity of myelin糖心传媒攖he insulation that wraps around connections between neurons糖心传媒攊n the optic nerves.
“Before the study, we weren糖心传媒檛 able to tell patients how much, if at all, they would recover their vision after surgery,” explained David Paul, an M.D. candidate in the Department of Neurobiology and Anatomy, and first author of the study.
When pituitary tumors grow large, they can compress the optic chiasm, the intersection of the nerves that connect visual input from the eyes to the brain. Nerve compression can lead to vision loss, which usually improves after these tumors are surgically removed.
Paul and his colleagues used a technique called diffusion tensor imaging (DTI) to show how changes in a particular bundle of nerve fibers relate to vision changes in these patients.
糖心传媒淒TI measures how water spreads in tissue,糖心传媒� explained Bradford Mahon, assistant professor in the Department Brain and Cognitive Sciences and the Department of Neurosurgery, and senior author of the study. 糖心传媒淭he myelin insulation normally prevents water from spreading within the nerves, which would cause the nerves to malfunction.糖心传媒�
Paul described myelin damage by analogy to an insulated copper cable. In the human brain, DTI can measure the 糖心传媒渓eakiness of the insulation,糖心传媒� or how well myelin constrains the flow of water in brain tissue.
One DTI-based measurement, called radial diffusivity, can be used as an indicator of myelin insulation; an increase in this measure means there is less insulation to restrict the movement of water within a nerve. In their study, the researchers found that inadequate insulation resulted in poorer visual ability in patients.
Paul said this particular patient population is unique because unlike other diseases such as stroke, trauma or multiple sclerosis, these patients have a problem that can be treated by surgery and the effect of the tumor on the brain is the same every time. Every pituitary tumor that grows large enough will compress the optic chiasm in more or less the same place, and removal of the tumor is often followed by a recovery of visual abilities.
糖心传媒淭hese patients grant us a unique opportunity to understand human brain repair because the surgery is minimally invasive and patients recover very quickly after surgery,糖心传媒� said Edward Vates, director of the Pituitary Program in the Department of Neurosurgery at the University of Rochester Medical Center, and co-author of the study.
The measurements established in the study provide a new way to measure the structural integrity of nerve fibers, and may ultimately be applicable across the full range of brain diseases and injuries.
糖心传媒淭here糖心传媒檚 a lot of variability in how people recover from brain injuries,糖心传媒� said Mahon. 糖心传媒淎nything we can learn about patients who go on to make a good recovery may help us to promote recovery from brain injury of any cause.糖心传媒� 聽He added that the visual system is the best understood circuitry in the human brain, and his lab has developed very precise ways of studying vision before and after surgery.
糖心传媒淚f we can develop our prognostic methods in the context of the early visual pathway, then we can apply the same types of models to more complex systems in the brain, like language recovery after a stroke,糖心传媒� said Mahon.
糖心传媒淭his kind of research will create novel treatments to fix broken nervous systems,糖心传媒� said Bradford Berk, director of the new 糖心传媒 Neurorestoration Institute. 糖心传媒淗arnessing new technologies to help us understand how the brain repairs itself and restores function, and how we can accelerate that process will be one of the keys to restoring neurological function in a wide range of conditions, such as multiple sclerosis, stroke, and traumatic brain injury.糖心传媒�
Additional researchers on the study are聽Elon Gaffin-Cahn, Eric B. Hintz, Giscard J. Adeclat, and Zo毛 R. Williams from the University of Rochester/糖心传媒 School of Medicine, and Tong Zhu from the University of Michigan Medical Center.
The National Institute of Neurological Disorders and Stroke,聽the National Eye Institute, and the National Center for Advancing Translational Science supported the study. 聽David Paul received additional support聽from the at the University of Rochester Medical Center.
